CXCR3 and malignant colon neoplasm: Similar to human breast and colon cancer cell lines [24,28], we found that growing BOWES cells under conditions of cellular stress (media without serum, incubated at 37°C with 8% CO2, hereafter referred to as stressed cultures) increased the proportion of cells expressing CXCR3 (Fig. 1C and 1D).