To further understand the consequences of CXCR3 expression in human melanoma cells and its role in the progression of BRAFWT melanomas in situ, we orthotopically injected 5 x 105 BOWES CXCR3 and BOWES PCMV6 cells intradermally in NSG mice (n = 16 mice per cell line). This evidence concerns the gene CXCR3 and melanoma.