AMG487 inhibits CXCR3 signaling by obstructing binding of CXCR3 ligands and has been shown to inhibit in vitro CXCR3-mediated cell migration by the CXCR3 chemokines, CXCL9, CXCL10, and CXCL11, and to inhibit lung metastasis in a mouse model of metastatic breast cancer [35]. This evidence concerns the gene CXCL9 and breast carcinoma.