IL-8 has also been shown to increase haptotactic migration in melanoma cells across a membrane [46], which supports our in vitro findings that BOWES CXCR3 cells, with increased IL-8 expression, have increased migration toward CXCL9 and CXCL10, and our in vivo findings that BOWES CXCR3 tumor tissue, with increased IL-8 expression, have increased metastasis to DLNs. This evidence concerns the gene CXCL8 and neoplasm.