IRF3 and chlamydia trachomatis infectious disease: The roles for IRF3 and IRF7 have been examined in C. muridarum infection, and it was shown that there was an initial IRF3-dependent IFN-β secretion that forms a positive feedback loop by inducing IRF7; which is then required for maximal IFN-β expression during chlamydial infection of murine peritoneal macrophages [28].