Because we were not able to disrupt late-infection synthesis of IFN-β in the Chlamydia-infected OE cells with BX-795, our results propose that the late-infection IFN-β synthesis involves the contributions from IRFs other than IRF3; which supports the observations of Pratner et al, demonstrating a role for IRF7 late during Chlamydia infection of peritoneal macrophages [28]. This evidence concerns the gene IFNB1 and chlamydia infectious disease.