It is not known whether the c-di-AMP can be detected in the culture medium during Chlamydia infection as in the Listeria studies, but because of its relationship to the endoplasmic reticulum (ER) membrane protein STING, it can be postulated that this di-nucleotide can be secreted from the cell through ER networks. This evidence concerns the gene STING1 and chlamydia infectious disease.