IFNB1 and infection: To test our hypothesis that Chlamydia infection induces the synthesis of secreted factors that can acclimatize cells for the optimal expression of innate-immune factors such as IFN-β, we next examined the effect that Chlamydia-infection conditioned media has on the transcription rates of several gene products found in signaling pathways of innate-immune mediators in uninfected OE cells [3].