Our previous investigations into the specific role of IFN-β induced during C. muridarum infection of OE cells revealed that IFN-β modulates the transcription of several other cytokines and chemokines induced during Chlamydia infection, and that IFN-β can restrict C. muridarum replication in TLR3-deficient OE cells [14]. This evidence concerns the gene TLR3 and chlamydia infectious disease.