IFNB1 and infection: We previously reported that C. muridarum induced IFN-β synthesis in OE cells can be detected in the supernatants by IFN-β specific ELISA as early as 4 h post infection, and the amount of IFN-β secreted into the supernatant steadily increased throughout the course of infection, with highest concentration levels being observed between 18–20 h post-infection [5].