Blocking NF-κB activity with JSH-23 seemed to have a minor effect on total IFN-β synthesis in C. muridarum-infected OE cells when added at 4 h post-infection; however, we routinely noticed only a minimal (but non-significant) decrease in IFN-β secreted when JSH-23 was added. The gene discussed is NFKB1; the disease is infection.