Our findings indicate that the IFNAR1 mediated pathway is indeed functional in OE cells, and that type-1 IFN can be induced through this pathway; however, data from these and our other ongoing investigation [19], show that IFNAR1 mediated signaling differentially induces the various type-1 IFNs throughout the course of Chlamydia infection in OE cells. Here, IFNAR1 is linked to chlamydia infectious disease.