Furthermore, the upregulation of bile acid synthetic enzymes CYP7B1 and CYP8B1 may be attributed, at least in part, to FXR reduction, which is associated with increased expression of their suppressors HNF4α and LRH-1 in human obstructive cholestatic liver [2, 6, 14]. The gene discussed is CYP7B1; the disease is digestive system neoplasm.