Furthermore, the upregulation of bile acid synthetic enzymes CYP7B1 and CYP8B1 may be attributed, at least in part, to FXR reduction, which is associated with increased expression of their suppressors HNF4α and LRH-1 in human obstructive cholestatic liver [2, 6, 14]. This evidence concerns the gene HNF4A and digestive system neoplasm.