In fact, in this paper, colocalization of NLRP3/ASC/mitochondria together with the inhibitory effect of mitoTEMPO (an inhibitor of mitochondrial ROS production) on CASP-1 maturation and cytokines activation in PBMC from CKD-HD patients confirm the involvement of this organelle. The gene discussed is CASP1; the disease is Huntington disease.