The current study focuses on the association of endophenotypes of POAG with SNPs rs1900004 and rs3858145 (ATOH7), rs10483727 (SIX1/SIX6), rs1192415 (CDC7), rs1063192 (CDNK2B) and rs9607469 (CARD10) in South Indian cohort. This evidence concerns the gene CARD10 and open-angle glaucoma.