Over-expression of anti-apoptotic factors such as BCL-XL has been postulated to play a role in mesothelioma pathogenesis.[11] Several receptor tyrosine kinases, including EGFR, PDGFR, KIT, VEGFR, and MET may drive mesothelioma growth; however attempts at targeted therapy towards these receptors have been unsuccessful.[12] Whole-genome analyses of pleural mesothelioma have identified a number of single-nucleotide variations (SNVs), as well as gross chromosomal alterations.[13] To our knowledge, results from whole-genome analysis of peritoneal mesothelioma have not been previously reported. This evidence concerns the gene EGFR and mesothelioma.