TP53 and pleural mesothelioma: Targeted panel sequencing identified a missense mutation in the smoothened gene (SMO V210M, COSM364081), a member of the hedgehog signaling pathway previously implicated in pleural mesothelioma.[18] A nonsense mutation in p53 (R213*, COSM10654), and a nonsense mutation in CDKN2A (R58*, COSM12473); the mutation in CDKN2A was identified only in the chemotherapy-resistant right colon nodule.