JAK2 and neoplasm: Whole-genome sequencing (107X tumor and 40X germline depth of coverage) identified a somatic frameshifting mutation in NF2 (Y177fs, COSM23800), as well as somatic SNVs in SOCS3 (N92K), an inhibitor of JAK2 tyrosine kinase;[15] TET3 (R870G), a gene involved in chromatin remodeling;[16] and TFPT (G128W) a promoter of apoptosis (Table 1).[17] One insertion/deletion, 13 additional SNVs, and 16 gross chromosomal aberrations were identified.