BAP1 and clear cell renal carcinoma: Similarly, the BRCA-associated protein 1 (BAP1) gene at 3p21 is also commonly lost or inactivated in mesothelioma.[7] Germline mutations in BAP1 are known to predispose carriers to mesothelioma,[8] and other malignancies such as uveal melanoma and clear cell renal carcinoma.[9]