By adding the [TIMP-2]×[IGFBP7] test to the postoperative clinical factors, the predictive power for AKI significantly improved (P<0.001); AUC 0.81 (95% CI 0.73, 0.90) increased to 0.89 (95% CI 0.83, 0.96). This evidence concerns the gene TIMP2 and acute kidney injury.