H1299, A549, and H322 cancer cells transfected with Ad-PKR (wild type PKR) or Ad-PKRΔ6 (mutant PKR) had comparable expression of PKR protein, but only cells transfected with Ad-PKR had increased expression of phosphorylated PKR at Thr451 (p-PKR) and phosphorylated eIF2α at Ser51 (p-eIF2α). Here, EIF2A is linked to cancer.