ATP2B3 and X-linked cerebellar ataxia: 2013). PMCAs have been reported to be associated with the pathogenesis of various human disorders. Pump dysregulation of nongenetic origin has been associated with cancer, and potential therapeutic opportunities by developing agents that modulate PMCA activity are being explored (Brini et al. 2013). Pump defects of genetic origin have also been described in PMCA2 and PMCA3, mutations of which cause hereditary deafness and X-linked cerebellar ataxia in humans, respectively (Strehler 2013).