IKBKE and major depressive disorder: Our previous study explored the single-nucleotide polymorphisms (SNPs) spanning the IL10 cytokine gene cluster on chromosome 1q32 and revealed a single SNP rs1539243 of the adjacent inhibitor of kappa light polypeptide gene enhancer in B cells, kinase epsilon (IKBKE) gene to be associated with the development of MDD and PD, although the result concerning MDD did not remain statistically significant after correction for multiple testing (Koido et al.