Activated uPA/uPAR and downstream proteinases also regulate the function of ECM-bound growth factors such as TGF-β, vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF), basic fibroblast growth factor (bFGF) and other growth factors implicated in cancer cell growth and angiogenesis [31]. The gene discussed is PLAU; the disease is cancer.