In contrast to the lungs, endothelial cells in the bone marrow constitutively express E-selectin.49,146 Studies have shown that E-selectin ligands on both human and mouse prostate cancer (PCa) cells facilitate bone metastasis in an E-selectin dependent manner.15,86,150 Instead of utilizing E-selectin knockout mice, these two studies overexpressed α-1,3 fucosyltransferases (FTs) in E-selectin ligand (ESL)-negative human and mouse PCa cell lines based on the findings that ESL-positive PCa cells highly express FT3, 6 or FT7. The gene discussed is SELE; the disease is Familial prostate cancer.