In their study, E- and P-selectin double knockout mice had a 84% reduction of lung metastatic nodules by number compared to wild-type mice after they were subcutaneously implanted with HT29 colon cancer cells.68 Lung endothelial cells, however, do not constitutively express E- and P-selectin unless they receive inflammatory signals. The gene discussed is SELP; the disease is malignant colon neoplasm.