CD40LG and atherosclerosis: There is evidence from preclinical studies that aspirin is able to inhibit the initiation (149) and even the progression of experimental atherosclerosis (150) via its effect on prostaglandin synthesis but also by other mechanisms such as the modulation of endothelial NO synthesis (151), NFκB signaling (152), CRP, or soluble CD40 ligand (sCD40L) (153).