Recently, Sergei Tevosian’s laboratory reported that Gata4/Gata6 double knockout mice generated with Sf1-cre exhibit severe adrenal hypoplasia; female double knockout mice die from adrenocortical insufficiency, whereas their male counterparts survive due to heterotopic glucocorticoid production by cells in the testes (107). This evidence concerns the gene SF1 and chronic primary adrenal insufficiency.