BDNF and Alzheimer disease: Turning back to animal models, it was recently shown that neurotrophin treatments used on transgenic mouse models of AD lead to a reduction in Aβ generation that was mostly dependent on the BDNF-mediated decrease in glycogen synthase kinase-3-β (GSK3β) activity, emphasizing the potential of neurotrophins as targets for disease modifying therapy (Kazim et al., 2014).