PRRT2 and Huntington disease: An interesting recent study by the Minichiello group in a novel genetic mouse model showed that the selective removal of BDNF from enkephalinergic striatal neurons results in spontaneous and drug-induced hyperlocomotion associated with dopamine D2 receptor-dependent increased striatal protein kinase C (PKC) and MAP kinase activation, a mechanism that may have impact on striatal neuron vulnerability in the early-stage of HD (Besusso et al., 2013).