Following miR-221 inhibition in MDA-MB-231 cells, reduced expressions of miR-10b along with reduced protein levels of uPAR, RHOC and the tumor cell invasion marker vimentin were observed, while the mRNA levels of all four uPAR isoforms were almost not affected indicating positive regulation of uPAR translation through miR-221. This evidence concerns the gene PLAUR and neoplasm.