At present, the physiological role of isoform 2 (uPAR7b) is not known in detail, but since it is overexpressed in several cancers and cancer cell lines [13, 14, 23], we hypothesize that miR-221−/−222-overexpressing cancer cells potentiate their malignant capacity through expression of a GPI-anchor-independent uPAR isoform that i) is C-terminally truncated (due to alternative splicing within exon 7 leading to GPI loss), therefore ii) it does not need to be additionally cleaved at the membrane and iii) still possesses chemotactic and ligand-binding properties (Figure 4C). This evidence concerns the gene PLAUR and cancer.