E2F1 and Familial prostate cancer: Furthermore, in prostate cancer, miR-31 was identified to negatively regulate E2F1, E2F2, EXO1, FOXM1, and MCM2, which are the key regulatory proteins in cell cycle regulation, and thereby demonstrated that the downregulation of miR-31 disrupts cellular homeostasis and contributes to the evolution and progression of prostate cancer.