Although we showed that ectopic miR-31 elicited inhibition of cellular growth of liver cancer cells through targeting HDAC2, it is necessary to prove that ectopic overexpression of 3′ UTR-deleted HDAC2 plasmid (pME18s-HDAC2-FLAG) can rescue the effects on cell cycle molecules in the same cells. The gene discussed is HDAC2; the disease is liver cancer.