To examine whether COX-2 expression is involved in Ku80-specific siRNA-mediated tumor growth suppression, we used LPS (lipopolysaccharides) to rescue COX-2 expression in mice treated with Ku80-specific siRNA, and found that LPS partially rescued the tumor growth inhibition caused by Ku80 siRNA treatment (Figure 6A-C). The gene discussed is XRCC5; the disease is neoplasm.