NOTCH1 and T-cell acute lymphoblastic leukemia: Although Notch signaling has been shown to play both oncogenic and tumor suppressor roles in cancer, depending on the cell type, increasing evidence has demonstrated the importance of Notch1 signaling in hematopoietic development and leukemia therapy [42], especially in AML and T-cell acute lymphoblastic leukemia (T-ALL) [43, 44].