In addition, consistent to our in vitro observations (Figure 4), transfection of VASH1-A significantly induced tumor cell senescence evidencing by the increased SA-β-Gal positive cell populations (Figure 6F and 6G); and transfection of VASH1-B markedly increased the apoptotic cells (cleaved caspase 3+ cells) in the tumor tissues (Figure 6H and 6I). The gene discussed is CASP3; the disease is neoplasm.