Importantly, Wang revealed the mechanism by which ATDC stabilizes β-catenin: in pancreatic cancer cells with high levels of ATDC, ATDC binds to and stabilizes Dvl-2 in the cytoplasm, resulting in the release of β-catenin from the destruction complex, which leads to increased β-catenin levels and activation of downstream β-catenin/TCF-regulated target genes. Here, HNF4A is linked to familial pancreatic carcinoma.