RNASET2 and ovarian carcinoma: To this end, the coding region of RNASET2 was engineered to introduce a KDEL endoplasmic-reticulum retention signal in order to prevent RNASET2 secretion, and the KDEL-modified RNASET2 construct was transfected into the Hey3Met2 human ovarian cancer cell line, which expresses very low levels of endogenous RNASET2 [5].