Since P-bodies represent intracellular sites where RNA turnover takes place and a complex mRNPs dynamics in these intracellular structures underlies cell response following stress challenges [31], our data further suggest that the in vitro response observed in ovarian cancer cells under hypoxic conditions might involve RNASET2-mediated processing of transcripts within these subcellular structures. This evidence concerns the gene RNASET2 and ovarian cancer.