Here, in the effects screen of CD44 knockdown acting on these transcription factors, we found that both mRNA and protein expression of Snail was strongly, consistently decreased in SMMC-7721 and MHCC97-H cells after CD44 inhibition, rather than Twist1, ZEB2 and FOXC2, indicating that CD44 knockdown may induce the MET of HCC cells through inhibiting Snail. Here, ZEB2 is linked to hepatocellular carcinoma.