Indeed, increasing evidence suggests that PTX3 expression may be a new diagnostic and prognostic marker of cancers, including pancreatic carcinoma, glioma malignancy, and lung carcinoma [16-18], however, neither the mechanisms of PTX3 transcriptional activation nor the functional role of PTX3 in the EGF-mediated HNSCC metastasis has clearly described. This evidence concerns the gene PTX3 and glioma.