The expressions of self-renewal-related genes, including SOX2 (4T1, 21.26 ± 3.06; CT26, 6.39 ± 0.82) and NANOG (4T1, 2.38 ± 0.86; CT26, 3.36 ± 0.72), and drug resistance-related genes, including ALDH1A1 (4T1, 3.98 ± 0.55; CT26, 18.9 ± 4.59) and ABCG2 (4T1, 1.55 ± 0.15; CT26, 1.96 ± 0.57), were relatively increased in cancer cells after co-culture with ADSCs. Here, SOX2 is linked to cancer.