TP53 and neoplasm: Given that TP53 is mutated in majority of NE tumor cells, which is important for progression of SCNC [44], it may help us to understand why compared with LNCaP cells that express wild-type p53, p53-null CL1 and PC-3 cells [33, 45] express low levels of miR-34a (Fig. 5E) [46].