CLCN5 and gonorrhea: In contrast to the response of p21WAF1 to miR-204 and XRN-siRNA, Cyclin D1 and Akt phosphorylation (both at T308 and S473) showed a significant up-regulation in the NEPC cell lines, but a down-regulation in the PAC cell lines overexpressing miR-204 (Fig. 5A and B).