We and others previously identified Y-box binding protein 1 (YB-1) and metastasis associated-1 (MTA1) as proteins regulated at the translation, and not mRNA transcription level downstream of the PI3K-AKT-mTOR signaling pathway, which is frequently deregulated in human prostate cancer [5, 7]. The gene discussed is YBX1; the disease is Familial prostate cancer.