KLK3 and Familial prostate cancer: For MTA1, the univariate analysis showed an increased risk for PSA recurrence associated with high protein levels in adjacent normal and PIN, but not prostate cancer tissues (adjacent normal: HR 1.24, 95% CI 1.05-1.47, P = 0.01; PIN: HR 1.30, 95% CI 1.06-1.61, P = 0.012; cancer: HR 1.14, 95% CI 0.98-1.34, P = 0.098) (Figure 2A).