Although all reported mutations in the TERT promoter including the causal –57 C > A germline single nucleotide change reported in a melanoma family are joined by a common feature of de novo creation of CCGGAA/T sequence, which, besides being a recognition motif for Ets transcription factors, is a specific binding motif for ternary complex factors like Elk1 and Elk4 [23]. The gene discussed is TERT; the disease is melanoma.