TERT and central nervous system cancer: A multivariate model on progression-free survival in low grade gliomas showed that TERT promoter mutations are associated with poor survival (HR = 10.2; 95% HR CI 1.9 – 55.9; P = 0.007) and 1p/19q codeletions have a protective effect (HR = 0.03; 95% HR CI 0.004 – 0.173; P = 0.0001) (Table 4).