We demonstrated that WIP1 silencing reduced MMP-9 and VEGF-C expression and the migration and invasion of ACC cells, and we also proved that overexpression of MMP-9 or VEGF-C restored the migration and invasion in WIP1 knockdown cells, indicating that MMP-9 and VEGF-C are downstream targets of WIP1 signaling. Here, PPM1D is linked to adrenal cortex carcinoma.