TRPM7 and neoplasm: Consistent with the observation that TRPM7 does not affect proliferation in vitro, mTRPM7 overexpression had no effect on mean tumor size (control = 0.35 ± 0.13 mm2, n = 118 tumors; mTRPM7 = 0.26 ± 0.03 mm2, p = 0.23, n = 786 tumors) (Figure 2D & 2E).