TRPM7 and cancer: Since SNAI2 is not only an important driver of neural crest formation and migration [6, 10, 43], but also a determinant of cancer stemness, migration and metastasis [4, 10, 11, 44], our results indicate that TRPM7 maintains progenitor features of neuroblastoma cells by controlling gene expression programs that involve the transcription factor SNAI2.