Since SNAI2 function is crucial to early neural crest specification, as well as EMT-driven delamination and survival of neural crest cells outside of the niche, down regulation of SNAI2 expression may underlie the distinct effects on developmental gene expression programs upon TRPM7 shRNA in N-type and S-type neuroblastoma cells [6, 10, 43, 44, 54]. This evidence concerns the gene TRPM7 and neuroblastoma.