Although the mechanism by which TRPM7 affects gene expression remains to be explored, our results suggest a model in which context dependent activation of TRPM7 reduces cytoskeletal tension, and through activation of transcriptional regulators that respond to cytoskeletal dynamics, such as YAP/TAZ and SRF [63, 64], controls the malignant features of neuroblastoma cells by promoting neural crest stem cell properties. Here, SRF is linked to neuroblastoma.