RPS6KB1 and non-small cell lung carcinoma: In two tested NSCLC cell lines, H460 and A549, rapamycin at 6 h treatment was equally effective in decreasing the levels of p-p70S6K, p-4EBP1 and p-S6, which are well-known readouts of the mTORC1, both in the absence and presence of SB216763.