In conclusion, the Bcl-2-selective BH3 mimetic ABT-199 is a promising agent for the treatment of B-cell malignancies including MCL and may be especially attractive in combination with BCR signaling inhibitory drugs such as ibrutinib, which can drive malignant cells out of the protective microenvironment of lymph nodes and bone marrow. This evidence concerns the gene BCR and mantle cell lymphoma.