The results of the current study revealed that SAHA treatment can suppress the tumor growth of H1299 lung cancer, decrease ALDHbr population but promote CSC characteristics, such as enhancement of the tumor initiating capacity and the expression of KCNMA1, MORF4L2 and ASPM genes in the residual subpopulation of cells with high ALDH activity residing in SAHA-treated xenografted tumor. The gene discussed is ASPM; the disease is lung cancer.