PSMB8 and cervical carcinoma: Furthermore, we have previously demonstrated that genetic variation in the genes encoding TAP2, LMP7 and ERAP1 is significantly associated with increased risk of developing cervical carcinoma and with poor prognosis among cervical carcinoma patients and that the effect of specific combinations of SNPs is cumulative as compared to the individual SNPs (Mehta et al. 2007, 2009).