In particular, we have shown previously that downregulation of endoplasmic reticulum aminopeptidase associated with antigen presentation 1 (ERAP1), transporter associated with antigen presentation 1 (TAP1) and low molecular weight peptide 7 (LMP7) is significantly associated with decreased survival in human papilloma virus (HPV) associated cervical carcinoma (Mehta et al. 2008). The gene discussed is PSMB8; the disease is cervical carcinoma.