AGT and Interstitial cardiac fibrosis: We hypothesized at the outset that ramipril might improve interstitial cardiac fibrosis by lowering circulating angiotensin II, a promoter of interstitial cardiac fibrosis,41 and losartan has previously been shown to cause regression of interstitial cardiac fibrosis and improvements in diastolic function in hypertensive patients.19 Our inability to demonstrate changes in T1 values (a surrogate marker of interstitial fibrosis30) may have been due to the imaging technique being insufficiently sensitive to pick up small changes in interstitial fibrosis.