Further small-scale, uncontrolled studies have included variations in the patients enrolled (aetiology and severity of liver disease), the method of cell harvest (direct BM aspiration or peripheral blood leukopharesis), the type and number of cells infused (various populations from unsorted mononuclear cells to purified CD133+ HSC) and the route of cell infusion (hepatic artery, portal vein or peripheral vein).3 The aim of many of these studies was to determine safety and feasibility and in that sense the outcomes were promising. This evidence concerns the gene PROM1 and liver disorder.