2009) and increased hypoxia (Szeto et al. 2009), both related to tumor aggressiveness. Based on these insights, IDH1 mutant tumors were expected to have lower \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\rho $$\end{document}ρ/D than IDH1 wild-type tumors. The gene discussed is IDH1; the disease is neoplasm.