PTGS2 and colorectal cancer: Nevertheless, the long-term benefits of laparoscopically assisted surgery in the management of colorectal cancer over open surgery remains, so interventions that minimize adverse events associated with laparoscopy are of potential merit.24 One potential intervention within convenient reach is to consider the use of COX-2 inhibitors, either contemporaneously or after insufflation and/or surgery to reduce peritoneal inflammation, particularly when dry-cold CO2 is used.