Of the 23 SMDs we identified for colon cancer, 20 were novel relative to domain types previously identified by Nehrt et al (we confirmed three domain types: the PI3K_p85B domain encoded by PIK3CA, the MH2 domain encoded by SMAD4 and the P53 DNA binding domain encoded by TP53). The gene discussed is SMAD4; the disease is malignant colon neoplasm.