TP53 and cancer: Of the 94 genes encoding at least one SMD, 40 (42%) had already been implicated in cancer according to the Sanger Cancer Gene Census (‘Cancer Census’) [39, 40], including well-established cancer-causing genes such as KRAS, EGFR and TP53. Enrichment for Cancer Census genes was both strong and significant (∼12-fold enrichment; P-value = 5×10–34, Fisher’s Exact test), and suggests the remaining 54 genes that are not already known to be cancer drivers represent good candidates.