Our previous study showed that the UPR is activated in tumor cells in a mouse model of medulloblastoma and that GADD34 inactivation enhances PERK signaling and facilitates the medulloblastoma formation by promoting angiogenesis through induction of vascular endothelial growth factor A (VEGF-A) [18]. The gene discussed is EIF2AK3; the disease is medulloblastoma.