ICAM1 and endothelial dysfunction: Inflammatory cytokines play important roles in the development and progression of atherosclerosis.[1] Cellular adhesion molecules, such as intercellular adhesion molecule 1 (ICAM-1), contribute to the inflammatory response and endothelial dysfunction.[2] They can mediate the margination, adhesion and transendothelial migration of circulating monocytes from the blood stream to the vessel wall.[3] They can also recruit and activate monocytes to release matrix metalloproteinases (MMP), promote plaque rupture and initiate acute coronary syndromes.