We therefore tested the hypotheses that (1) ADCY5 mRNA expression in adipose tissue is related to obesity, fat distribution and T2D in humans, (2) ADCY5 rs11708067 genotype contributes to alterations in ADCY5 expression and phenotype and (3) high fat feeding of mice results in ADCY5 expression changes in AT. This evidence concerns the gene ADCY5 and type 2 diabetes mellitus.