ADCY5 and obesity due to melanocortin 4 receptor deficiency: Moreover, Windholz et al. [5] reported associations of the ADCY5 rs2877716 variant—which is in LD with rs11708067 tested in our work—with parameters of insulin secretion and action (fasting plasma insulin, peak insulin, QUICKI and Matsuda insulin sensitivity index), but not with obesity related traits in obese Caucasian children.