Although aberrant activity of the NLRP-3 inflammasome and IL-1β has been implicated in the pathophysiology of various inflammatory skin diseases [27–29] and has been shown to contribute to impaired healing in diabetic wounds [20,25,30], less is known regarding the role of the NLRP-3 inflammasome during normal skin wound healing. The gene discussed is NLRP3; the disease is inflammatory skin disease.