TARDBP and amyotrophic lateral sclerosis: Moreover, on the basis of the neuropathological evidence of progressive stages of TDP-43 pathology affecting specific fiber tracts [23], significant differences between ALS patients and controls for these WM fiber bundles have been recently shown in vivo by using a new tract of interest-based fibre tracking approach [26], thereby identifying the DTI correlates of the previously described immunohistochemical stages of disease [23].