TARDBP and amyotrophic lateral sclerosis: Moreover, similarly to what observed in other neurodegenerative diseases characterized by tau and alfa-sinuclein pathology [17–19], there is increasing evidence that in ALS-FTLD spectrum the aggregation of transactive response DNA binding protein 43 KDa (TDP-43) could sequentially disseminate during disease course from a focal site of onset in a prion-like, cell-to-cell manner [20].