It is worth noting that, although we showed some correspondence between the progressive extent of microstructural abnormalities across three clinical stages of ALS and the spreading pattern of TDP-43 pathology previously described by Brettschneider et al. [23], we did not aim to explore the DTI and VBM correlates of TDP-43 stages of disease, as performed in a recent fiber tracking analysis by Kassubek et al. [26]. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.