In conclusion, the findings of the present study indicated that SNPs located at DROSHA, DICER1, SND1, TNRC6B, TRBP and CNOT1 genes, involved in miRNAs biogenesis pathway, as well as in miR196a2 and miR1206 may contribute to the risk of CLL. The gene discussed is SND1; the disease is B-cell chronic lymphocytic leukemia.