In addition, a recent study in lung cancer has demonstrated that the polymorphism rs640831 in high LD with rs3805500 (r2>0.8) was associated with reduced DROSHA mRNA expression and with expression changes in 56 miRNAs out of 199 analyzed [32], some of which could also regulate genes involved in the development of CLL. Here, DROSHA is linked to B-cell chronic lymphocytic leukemia.