NOS3 and Stroke: In multiple ischemic cardiovascular diseases including stroke[40], coronary artery disease [41], and peripheral arterial occlusive disease[42], the pathological plasma levels of ADMA and LNMMA are higher and well within range of their endothelial NOS inhibitory constants (Ki, 0.9 μM and 1.1 μM respectively [4]) thus establishing conditions necessary for NO dysregulation.