Here we report on the evaluation of seven of these protein biomarkers (IGFBP2, PKM2, DKK3, MAC2BP, tissue inhibitors of metalloproteinases 1 (TIMP1), Interleukin 8 (IL8) and Interleukin 6 (IL6) as a potential diagnostic or screening test for CRC. This evidence concerns the gene CXCL8 and colorectal carcinoma.