PKM and colorectal carcinoma: Similarly, PKM2 also proved to be the most successful marker at identifying CRC at each disease stage when compared to the control population in this particular study, including early stage disease (sensitivities of 48% (p = 0.0008), 52% (p<0.0001), 61% (p<0.0001) and 75% (p<0.0001) for Stages I, II, III and IV, respectively in the training cohort and sensitivities of 52% (p<0.0001), 65% (p<0.0001), 54% (p<0.0001) and 80% (p<0.0001) for Stages I, II, III and IV, respectively in the test cohort) (S1 Table).