Furthermore, being adjusted by positive lymph nodes, tumor size >5 cm, negative hormone receptor status, HER-2-postive status, chemotherapy, radiation and hormone therapy in multivariate analyses, AA genotype remained an independent prognostic factor for DFS (HR = 0.456, 95% CI = 0.249–0.836, P = 0.011) (Table 4). Here, NR4A1 is linked to neoplasm.