AFF1 and acute lymphoblastic leukemia: For instance, cyclin-dependent kinase 6 (CDK6), which was identified as one of the MLL fusion target genes, as the genomic region encompassing CDK6 revealed enhanced occupancy of both MLL-AF4 and H3K79 dimethylation.[8] We recently reported data showing the important role of CDK6 in the proliferation of MLL-rearranged ALL cells, demonstrating experimentally that inhibition of CDK6 readily induces impairment of leukemic cell proliferation.