KMT2A and acute lymphoblastic leukemia: A hallmark of acute lymphoblastic leukemia (ALL) in infants (<1 year of age) is a high incidence (∼80%) of chromosomal translocations involving the Mixed Lineage Leukemia (MLL) gene [1, 2], in which the N-terminal portion of MLL fuses to the C-terminal region of one of its many translocation partner genes.