The mechanisms by which hyperleptinemia contributes to hypertension include the following: activation of the sympathetic nervous system innervating the kidneys [20, 21], increase in circulating endothelin-1 (ET-1) [22], increase in oxidative stress, decrease in nitric oxide [15, 16] and increase in sodium retention [16, 23]. This evidence concerns the gene EDN1 and hypertensive disorder.